Impureza relacionada ao bupropion | Bupropion Related Compound D (HCl Salt) | conhecida como Deschloro Bupropion Hydrochloride ou cloridrato descloro do bupropion | CAS 63199-74-6 | representa uma impureza de processo e degradação que requer monitoramento rigoroso em matérias primas e produtos acabados. A molécula | de natureza salina e moderada solubilidade em água | demanda métodos analíticos sensíveis como HPLC com deteção UV e LC MS para identificação e quantificação | além de estudos de extração e purificação. O controlo desta impureza é fundamental para a conformidade com especificações | validação de método | investigação de estabilidade e mitigação de riscos toxicológicos e farmacocinéticos.
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