A Impureza EP F da buspirona, também designada impureza dimerizada de anel aberto da buspirona, é um degradante dimérico relacionado ao processo, associado à abertura estrutural do esqueleto azaspirobuspirona durante a síntese ou sob condições de estresse posteriores. O CAS 2512210-24-9 corresponde a C33H51N9O3, com massa molecular de 621,82 g/mol. A espécie apresenta vários nitrogênios básicos e um arcabouço não ciclado do tipo diamina, o que pode alterar o comportamento cromatográfico e a fragmentação em espectrometria de massas. A caracterização em traços normalmente requer LC-MS/MS, frequentemente complementada por MS de alta resolução e métodos ortogonais de LC em fase reversa ou por par iônico. Seu controle é relevante em perfis de impurezas farmacopéicas e ICH.
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