Impureza cloro metil do citalopram refere-se a um subproduto halogenado gerado durante etapas de clorometilação na síntese do fármaco; sua presença altera o perfil de pureza do lote e exige monitoramento analítico rigoroso. Caracteriza-se por massa molecular e fragmentação compatíveis com substituição cloro-metil no anel aromático | frequentemente detectável por HPLC com detecção UV | LC-MS e RMN para confirmação estrutural. O controle desta impureza é crítico para atender especificações de qualidade e segurança do processo | minimizando riscos de contaminação cruzada e permitindo otimização da rota sintética por etapas de purificação e parâmetros reacionais validados.
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