D-Phe-Teriparatida é uma impureza peptídica estereoquímica da teriparatida, originada por incorporação incorreta ou inversão epimérica no resíduo de fenilalanina durante a síntese em fase sólida ou no manuseio subsequente. Essa variante não nativa com aminoácido D pode alterar o reconhecimento do receptor, o comportamento conformacional e a estabilidade proteolítica, sendo relevante no perfil de impurezas e na avaliação de estabilidade. Como não há fórmula molecular nem massa molecular definidas, a caracterização depende de LC-MS de massa intacta, mapeamento peptídico por LC-MS/MS e separação cromatográfica quiral ou ortogonal. A avaliação regulatória se concentra na confirmação estrutural, abundância relativa e origem como variante de processo ou degradação.
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