Impureza Deoxy Donepezil (CAS 844694-84-4) | também referida como 4-[(2 | 3-dihidro-5 | 6-dimetoxi-1H-inden-2-il)metil]-1-(fenilmetil)piperidina cloridrato | é um perfil de impureza relevante em matérias-primas e produtos à base de donepezil. Caracteriza-se por modificação no anel inden e perda de oxigênio relativa à molécula parental | exigindo monitoramento rigoroso por técnicas analíticas como cromatografia líquida acoplada a espectrometria de massa e ressonância magnética nuclear para identificação e quantificação. A presença desta impureza pode afetar o perfil de pureza e estabilidade do lote e deve ser avaliada conforme diretrizes regulatórias para garantir segurança | conformidade e qualidade do produto farmacêutico.
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