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120014-30-4Donepezil EP Impurity A

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Nº do catálogo:	VE006102
Nº CAS:	120014-30-4
Fórmula Mol.::	C17H23NO3
Peso Mol.::	289.4 g/mol

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Informações adicionais sobre o CAS 120014-30-4

Fármaco de origem

Donepezil

Nome IUPAC

5, 6-Dimethoxy-2-(piperidin-4-ylmethyl) indan-1-one

Sinônimos farmacopeicos

Desbenzyl Donepezil

Outros sinônimos

5,6-dimethoxy-2-(piperidin-4-yl)methylene-indan-1-one; 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-(4-piperidinylmethyl)-; 5,6-dimethoxy-2-(piperidin-4-ylmethyl)-2,3-dihydroinden-1-one; 5,6-Dimethoxy-2-piperidin-4-ylmethyl-indan-1-one; 4-((5,6-Dimethoxy-1-oxoindan-2-yl)methyl)piperidine;(acetyloxy)tributyl-Stannane;

SMILES

O=C1C(CC2CCNCC2)CC3=C1C=C(OC)C(OC)=C3

InChI

InChI=1S/C24H20N6O3/c1-2-33-23(31)19-8-5-9-20-21(19)30(24(32)25-20)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,25,32)(H,26,27,28,29)

Condição de envio

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Dados adicionais de caracterização

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Descrição

Donepezil EP Impurity A known in pharmacopoeias as Desbenzyl Donepezil is a thoroughly characterized reference standard. It meets strict regulatory standards including those set by USP EMA JP and BP. This product is crucial for use in Abbreviated New Drug Applications (ANDA) New Drug Applications (NDA) and the commercial production of Donepezil. Additionally it comes with a detailed Structure Elucidation Report (SER) ensuring its precision and dependability for a variety of analytical uses. Also known as Desbenzyl Donepezil (free base ), it is a process-related impurity of Donepezil drug which is a specific, selective, and potent inhibitor of acetylcholinesterase an approved drug for the treatment of Alzheimer’s disease.

Referências

Krishna Reddy, K. V. S. R., et al. “Identification and Characterization of Potential Impurities of Donepezil.” Journal of Pharmaceutical and Biomedical Analysis, vol. 35, no. 5, Sept. 2004, pp. 1047–58, https://doi.org/10.1016/j.jpba.2004.03.022.