Ethyl Valproate (CAS 17022-31-0) é uma impureza de síntese identificada como éster etílico do ácido valpróico | também referida como ethyl 2-propylpentanoate ou ethyl dipropylacetate. Do ponto de vista analítico é relevante por sua coeluição potencial em HPLC e por sua volatilidade relativa que afeta quantificação por GC. A caracterização exige métodos confirmatórios como LC-MS/MS e RMN para estabelecer identidade e pureza | e estudos de perfil de degradação para entender vias formadoras durante esterificação. Em controle de qualidade deve constar em especificações por limites baseados em toxicidade e qualificações regulatórias | com estratégias de redução na síntese e limpeza de processo.
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