Ibuprofen EP Impurity D, CAS 938-94-3, corresponde ao ácido 2-(4-metilfenil)propanoico, um isómero posicional do ibuprofeno com fórmula C10H12O2 e massa molecular de 164,2 g/mol. Esta impureza do tipo ácido arilpropiónico pode resultar da formação do isómero durante a síntese ou do controlo insuficiente de etapas de alquilação regioseletiva no fabrico. Não se trata de uma nitrosamina nem de uma espécie mutagénica, mas a sua presença é relevante para o perfil de impurezas e para a conformidade compendial. A identificação geralmente exige HPLC com deteção por arranjo de diodos, LC-MS/MS para confirmação de massa e, quando aplicável, GC-MS após derivatização.
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