Leflunomide BP Impurity E; Teriflunomide Isoxazole Impurity; 3-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide;
Descrição
Leflunomide EP Impurity E (CAS 208401-20-1) | também conhecida como Leflunomide BP Impurity E | Teriflunomide Isoxazole Impurity ou 3-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide | é uma impureza isoxazol derivada da via sintética da leflunomida. Caracteriza-se pelo núcleo isoxazol e pelo grupo trifluorometil no anel fenil | e pode originar-se por isomerização ou reações laterais durante síntese | purificação ou armazenamento. É alvo de controlo analítico por HPLC-UV | LC-MS e RMN | devido ao seu impacto potencial na pureza e estabilidade do ativo. Procedimentos de controlo e especificações farmacopoeiais são empregados para limitar sua presença no material final.
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