2-Butyl-4-chloro-5-(hydroxymethyl)imidazole; 2-n-Butyl-4-chloro-5-(hydroxymethyl)imidazole; 5-Chloro-2-butyl-imidazole-4-methanol; Losartan EP Impurity A
Descrição
Losartan EP Impurity A (CAS 79047-41-9) | também referida como 2-Butyl-4-chloro-5-(hydroxymethyl)imidazole | é uma impureza sintética com relevância no controle de qualidade de losartana. Apresenta estrutura imidazólica substituída por grupo butil | cloro e hidroximetil | o que influencia polaridade e perfil de retenção cromatográfica. É detectada e quantificada por HPLC com detector UV e confirmada por LC-MS e RMN para avaliação de identidade e pureza. A compreensão de sua formação | estabilidade e limites aceitáveis é essencial para validação analítica | avaliação de risco toxicológico e conformidade com perfis de impurezas farmacêuticas.
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