Losartan Potassium Related Compound C; 2-Butyl-4-chloro-1-[[2?-(1H-tetrazol-5-yl)[1, 1?-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde; EXP 3179; DUP 167; Losartan EP Impurity K; Losartan USP Related Compound C; 2-Butyl-4-chloro-1-[[2?-(1H-tetrazol-5-yl)[1, 1?-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde; EXP 3179; DUP 167; Losartan EP Impurity K; Losartan USP Related Compound C
Descrição
Losartan Potassium Impurity C (CAS 860644-28-6) | também denominada Losartan Potassium Related Compound C ou EXP 3179 | é um subproduto estruturalmente caracterizado por um anel imidazólico com função carboxaldeído e uma unidade biphenil-tetrazol substituída. Esta impureza influencia a qualidade do fármaco ativo quando presente acima dos limites estabelecidos e é monitorada por métodos analíticos sensíveis como HPLC com detecção UV e LC-MS para confirmação de massa. A formação pode ocorrer por oxidação ou desproteção durante etapas sintéticas. O controle inclui otimização das condições de reação | purificação cromatográfica e especificações de lote para garantir conformidade regulatória e estabilidade do produto final.
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