N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide (CAS 890028-66-7) é uma impureza de síntese caracterizada por um núcleo pirimidínico substituído e um grupo sulfonamida N-metil. Seu perfil analítico requer identificação e quantificação por HPLC acoplada a LC-MS e confirmação estrutural por 1H e 13C NMR, com avaliação de pureza e impurezas relacionadas. Pode originar-se de reações de acilação incompleta ou degradação oxidativa e impactar estabilidade e perfil toxicológico do produto final. Recomenda-se monitorização do seu nível, desenvolvimento de métodos validados e estratégias de controle conforme orientações ICH para qualificação de impurezas.
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![N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide](https://veeprho.com/wp-content/uploads/2026/01/N-4-4-Fluorophenyl-6-isopropyl-5-1E-3-oxo-1-propenyl-2-pyrimidinyl-N-methyl-methanesulfonamide-890028-66-7-VE0026767-sqr.png "N-[4-(4-Fluorophenyl)-6-isopropyl-5-[(1E)-3-oxo-1-propenyl]-2-pyrimidinyl]-N-methyl-methanesulfonamide")
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