A Impureza F da fenilefrina (Phenylephrine Impurity F | CAS 581-96-4) corresponde ao ácido naftalenoacético naphthalen-2-ylacetic acid | caracterizado por um núcleo naftaleno ligado a um grupo carboxílico acético. Essa impureza aromática apresenta solubilidade reduzida em água e maior lipofilicidade | influenciando perfil de solubilidade e estabilidade do lote. No controle analítico é monitorada por técnicas como HPLC-UV | LC-MS e RMN para identificação e quantificação | permitindo estabelecer limites de aceitação conforme exigências regulatórias. Sua presença como subproduto sintético pode indicar variações de processo ou reagentes | tornando essencial investigação de origem e estratégias de limpeza e purificação.
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