Regorafenib EP Impurity A, também designado Regorafenib Related Compound A, é identificado pelo CAS 757251-39-1 e apresenta fórmula molecular C13H12FN3O2, com massa molecular de 261.26 g/mol. A estrutura corresponde a um intermediário sintético definido ou a uma impureza associada ao processo, relacionada à construção do motivo heteroarílico fluorinado substituído presente no regorafenib. Essas espécies são habitualmente monitoradas em perfis de impurezas, pois podem indicar conversão incompleta, reações secundárias ou arraste de precursores. A determinação geralmente requer LC-MS de alta resolução, LC-MS/MS e HPLC específica para impurezas com detecção por UV, com confirmação estrutural por RMN quando necessário.
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