Telmisartan EP Impurity B, também denominada Telmisartan Related Compound B ou Telmisartan Isomer, é um isómero estrutural do antagonista do recetor de angiotensina II do tipo bifenil tetrazol. O CAS 1026353-20-7 corresponde a uma impureza isomérica neutra e não clássica, com fórmula molecular C33H30N4O2 e massa molecular de 514.62 g/mol. A sua formação está geralmente associada a isomerização na rota sintética ou a rearranjos em fase tardia, e não à degradação oxidativa. Como isómeros posicionais podem coeluir com o API, a caracterização depende frequentemente de LC-MS/MS, LC-MS de alta resolução e separação cromatográfica ortogonal, com confirmação por RMN quando necessário. É controlada como impureza relacionada ao processo segundo critérios farmacopeicos.
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