tert-Butyl [(1R,2S,5S)-2-amino-5 [(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate oxalate EthanediaMide iMpurity A
Descrição
Impureza tert-butyl ((1S | 2S | 5R)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate | na forma de sal mesilato | é um subproduto estereoquímico que apresenta grupo carbamato tert-butílico | amina secundária no anel cicloxexílico e uma função dimetilcarbamóila que altera polaridade e solubilidade; identificada também em variantes oxalato e referida como EthanediaMide Impurity A | esta impureza impacta o perfil de pureza e pode originar-se por epimerização ou reações incompletas durante etapas de proteção. A sua deteção e quantificação exigem métodos analíticos validados como HPLC com deteção UV | LC-MS e RMN para discriminação estereoquímica | e o controlo passa por otimização de etapas sintéticas e purificação por cromatografia.
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