Zusätzliche Informationen zu Acyclovir EP Impurity Q
Parent drug
Acyclovir
IUPAC-Name
2-Amino-9-(((2-hydroxyethoxy)methoxy)methyl)-1,9-dihydro-6H-purin-6-one compound with 2-amino-9-((2-(hydroxymethoxy)ethoxy)methyl)-1,9-dihydro-6H-purin-6-one (1:1)
Synonyme
N/A
Beschreibung
Acyclovir EP-Impurity Q ist eine strukturell verwandte Nukleosid-Verunreinigung mit der Formel C18H26N10O8 und einer Molmasse von 510,46. Die Zusammensetzung weist auf ein stark funktionalisiertes, aus Guanin abgeleitetes Analogon hin, vereinbar mit einem oxidierten oder überacetylierten Synthesenebenprodukt und nicht lediglich mit einem einfachen Prozessrückstand. Solche Spezies können während mehrstufiger Schutzgruppen-, Glycosylierungs- oder Endentschutzungssequenzen in der Acyclovir-Herstellung entstehen. Da eng verwandte Purinverunreinigungen die Spezifität der Gehaltsbestimmung und das Verunreinigungsprofil beeinflussen können, erfordert die Charakterisierung typischerweise RP-LC gekoppelt mit hochauflösender MS, häufig ergänzt durch MS/MS-Fragmentierung und orthogonale LC-UV-Methoden zur Spurenanalyse.
References
O’Brien, John J., and Deborah M. Campoli-Richards. “Acyclovir.†Drugs, vol. 37, no. 3, Mar. 1989, pp. 233–309, 10.2165/00003495-198937030-00002.
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