Diclofenac Alcohol; Diclofenac Related Compound B; 2-[(2, 6-Dichlorophenyl)amino]benzenemethanol; [2-[(2, 6-Dichlorophenyl)
Beschreibung
Diclofenac EP Impurity C, auch als Diclofenac Related Compound C oder Diclofenac Alcohol Analog bezeichnet, ist eine benzhydrolartige Verunreinigung, die dem reduzierten Alkohol-Derivat von Diclofenac entspricht. CAS 27204-57-5; Summenformel C13H11Cl2NO; Molekulargewicht 268,14 g/mol. Die Verbindung kann durch Überreduktion sowie durch synthetische oder metabolische Nebenwege der Carboxylfunktion entstehen. Obwohl kein Nitrosamin, stellt sie eine strukturrelevante prozessbedingte Verunreinigung dar, die nach den Prinzipien der Verunreinigungsqualifizierung zu überwachen ist. Die Spurenbestimmung erfordert üblicherweise LC-MS/MS, LC-HRMS und orthogonale HPLC-Verfahren; UV-Detektion ist für die sichere Identifizierung häufig unzureichend.
References
Lu, Yuqing, et al. “PEI-Modified Core-Shell/Bead-like Amino Silica Enhanced Poly (Vinyl Alcohol)/Chitosan for Diclofenac Sodium Efficient Adsorption.†Carbohydrate Polymers, vol. 229, Feb. 2020, p. 115459, https://doi.org/10.1016/j.carbpol.2019.115459.?Tang, Wei. “The Metabolism of Diclofenac – Enzymology and Toxicology Perspectives.†Current Drug Metabolism, vol. 4, no. 4, Aug. 2003, pp. 319–29, https://doi.org/10.2174/1389200033489398.?
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