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949096-01-9Duloxetine EP Impurity C

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Katalog-Nr.::	VL202012
CAS-Nr.::	949096-01-9
Summenformel::	C18H19NOS
Molare Masse::	297.41 g/mol

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Zusätzliche Informationen zu CAS 949096-01-9

Parent drug

Duloxetine

IUPAC-Name

4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl]naphthalen-1- ol HCl

Synonyme

Duloxetine 4-Napthyl Isomer; Duloxetine Impurity

SMILES

CNCCC(C1=CC=C(C2=CC=CC=C21)O)C3=CC=CS3.Cl

Beschreibung

Duloxetine EP Impurity C or Duloxetine 4-Napthyl Isomer (CAS No.949096-01-9) or 4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl]naphthalen-1- ol HCl. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450.

References

Carter, Natalie J., and Paul L. McCormack. Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. ?Knadler, Mary Pat, et al. Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-000000000-00000 ‚