N-Nitroso bis(2-chloroethyl)amin (CAS 67856-68-2), Summenformel C4H8Cl2N2O, Molekülmasse 171,02 g/mol, ist ein dichlorierter Alkylnitrosamin mit ausgeprägter elektrophiler Reaktivität und alkylierendem Verhalten. Diese Verunreinigung kann aus der Nitrosierung von Vorstufen auf Basis von Bis(2-chlorethyl)amin oder aus prozessbedingter Kontamination bei der Herstellung chlorethylierender Reagenzien entstehen. Als genotoxische Verunreinigung fällt sie in den risikobasierten Kontrollrahmen der ICH M7. Für den Nachweis werden in der Regel hochselektive Verfahren wie LC-MS/MS oder GC-MS eingesetzt, häufig unter Verwendung von Isotopenverdünnung aufgrund niedriger Grenzwerte und Spurenkonzentrationen.
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