1-(4-fluorofenil)-5-ftalano carbonitrilo (CAS 64169-67-1) | también conocido como Citalopram Inhouse Impurity C | es una impureza orgánica aromática observada en el perfil de impurezas del clorhidrato de citalopram; su estructura nitrilo-fenil-ftalano le confiere carácter relativamente lipofílico y baja volatilidad | lo que complica su eliminación por medios físicos. La identificación y cuantificación requieren técnicas analíticas robustas como HPLC con detección UV o MS | LC-MS/MS y confirmación por RMN y espectrometría de masas. Se recomienda su inclusión en estudios de estabilidad y degradación forzada y el establecimiento de límites de especificidad junto con métodos validados de control de calidad y cumplimiento regulatorio.
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