Citalopram USP Related Compound G / Citalopram 5-Chloro Analog HBr
Descripción
Citalopram EP Impurity E (CAS 64169-46-6) | también denominada Citalopram USP Related Compound G o Citalopram 5-Chloro Analog HBr | es una impureza estructural relevante en el control de calidad del citrato de citalopram. Su formación puede ocurrir como análogo clorado durante etapas de síntesis o por reacciones secundarias bajo condiciones de proceso. Técnicamente se caracteriza por diferencias de polaridad y masa molecular detectables por HPLC | LC MS y resonancia magnética nuclear | y requiere especificaciones cuantitativas en conformidad con ICH. La identificación | cuantificación y eliminación mediante etapas de purificación y controles en proceso son críticos para asegurar pureza | impurezas relacionadas y estabilidad del lote final.
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