Citalopram EP Impurity D | sal de clorhidrato | CAS 97743-99-2 | conocida también como N-desmetil citalopram HCl | EsCitalopram EP Impurity D o Citalopram Related Compound D | es una impureza crítica en el perfil analítico del citalopram. Su estructura derivada del núcleo isobenzofurancarbonitrilo y el fragmento 4-fluorofenilo exige un control riguroso mediante HPLC | LC-MS y RMN para la identificación y cuantificación a niveles traza. El seguimiento de esta impureza permite mapear vías de degradación | optimizar pasos sintéticos y procesos de purificación | y garantizar cumplimiento con monografías EP y requisitos de calidad y seguridad farmacéutica.
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