Indomethacin Impurity 3 (sal sódica) | CAS 5446-07-1 | es una impureza reconocida en la síntesis y purificación de indometacina cuya identificación y control son esenciales para la conformidad regulatoria; presenta un perfil cromatográfico definido y masa molecular detectable por HPLC con detección UV y LC-MS | y su estructura se confirma mediante RMN. Su solubilidad y propiedades fisicoquímicas pueden diferir de la forma ácida | influyendo en la estabilidad y en los límites de impurezas relacionadas. Se recomienda establecer especificaciones según directrices ICH | aplicar métodos analíticos validados para cuantificación | y mantener condiciones de almacenamiento y documentación de trazabilidad para control de calidad.
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