2-Amino-Adenosina como impureza se caracteriza por la presencia de un grupo amino en posición 2 del anillo adenina unido a la ribosa | lo que altera la polaridad | solubilidad y espectro UV respecto al compuesto principal. Su identificación y cuantificación requieren métodos analíticos sensibles como HPLC con detección UV | cromatografía de líquidos acoplada a espectrometría de masas y RMN para confirmación estructural. Esta impureza puede formarse por reacciones de aminación incompleta o degradación durante etapas de síntesis y almacenamiento | y puede impactar la potencia y seguridad de lotes si no se controla. Se recomiendan límites de especificación | estudios de estrés y procedimientos de purificación validados.
Referencias
Long, Mary C., et al. “Identification and Characterization of a Unique Adenosine Kinase from Mycobacterium Tuberculosis.† Journal of Bacteriology, vol. 185, no. 22, Nov. 2003, pp. 6548–55,  https://doi.org/10.1128/jb.185.22.6548-6555.2003.
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