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118-00-3Adenosine EP Impurity H
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| Catalogue No.: | VE007800 |
|---|---|
| CAS No.: | 118-00-3 |
| Mol. Formula: | C10H13N5O5 |
| Mol. Weight: | 283.2 g/mol |
Additional information on CAS 118-00-3
Parent drug
AdenosineIUPAC Name
2-Amino-9-Beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-onePharmacopeial Synonyms
GuanosineSynonyms
guanine riboside; vernine; Guanozin; Guanosin; 2-Amino-1,9-dihydro-9-beta-D-ribofuranosyl-6H-purin-6-one; Guanine-9-beta-D-ribofuranoside; 9-beta-D-Ribofuranosylguanine; Ribofuranoside, guanine-9, beta-D-; 2(3H)-Imino-9-beta-D-ribofuranosyl-9H-purin-6(1H)-one; 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 2-Amino-9-beta-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one; 9-.beta.-D-ribofuranosylguanine; [3H]-guanosine; Inosine, 2-amino; Guanine-9-ss–D-ribofuranoside; 9-beta-delta-ribofuranosyl-GuanineSmiles
O=C1NC(N)=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)O)OInChI
InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1Shipping Condition
Ambient TemperatureDescription
Adenosine EP Impurity H, identified as guanosine (CAS 118-00-3), is a structurally related nucleoside impurity encountered during adenosine synthesis and stability studies. Molecular formula C10H13N5O5 and exact mass 283.24 Da facilitate mass spectrometric identification with a characteristic [M+H]+ at m/z 284. Reversed-phase HPLC separates guanosine from adenosine with distinct retention behavior and UV absorbance near 254 nm, while 1H and 13C NMR confirm ribofuranosyl and guanine resonances. Water solubility and thermal decomposition profiles support analytical method development. Routine control by validated HPLC and MS methods ensures compliance with pharmacopoeial impurity limits.References
Lanznaster, Débora, et al. “Guanosine: A Neuromodulator with Therapeutic Potential in Brain Disorders.” Aging and Disease, vol. 7, no. 5, 2016, p. 657, https://doi.org/10.14336/ad.2016.0208. ?Request a Quote
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