N, N-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethanamine oxide
Sinónimos
1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine 1-oxide; Almotriptan Related Compound D; Almotriptan EP Impurity E
Descripción
Almotriptan N-Oxide (CAS 603137-43-5) | conocido también como 1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine 1-oxide | Almotriptan Related Compound D y Almotriptan EP Impurity E | es una impureza oxidativa relevante en el control de calidad de Almotriptan. Desde el punto de vista técnico presenta aumento de masa y polaridad frente al API parental | lo que favorece su detección por HPLC con detección UV y confirmación por LC-MS y espectrometría de masas exacta. Su monitoreo es esencial para validar límites de impurezas | estudiar rutas de degradación por oxidación y optimizar condiciones de síntesis y almacenamiento para minimizar su formación y garantizar cumplimiento regulatorio.
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