N, N-dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)methyl)-1H-indol-3-yl)ethanamine oxide
Sinônimos
1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine 1-oxide; Almotriptan Related Compound D; Almotriptan EP Impurity E
Descrição
Almotriptan N-Oxide (CAS 603137-43-5) | também referida como 1-(((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)sulfonyl)pyrrolidine 1-oxide | Almotriptan Related Compound D ou Almotriptan EP Impurity E | é uma impureza oxidativa do almotriptano identificada em estudos de estabilidade e síntese. Apresenta massa molecular e assinaturas espectroscópicas detectáveis por LC-MS e 1H NMR | e é quantificada rotineiramente por HPLC em métodos de controle de qualidade. A sua formação relaciona-se com condições de oxidação durante o processo de fabricação e armazenamento | tornando essencial caracterizar o perfil | estabelecer limites aceitáveis e definir estratégias de remoção para conformidade regulatória.
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