La Impureza J de Budesonida EP, CAS 313474-59-8, es un subproducto de degradación o de proceso brominado relacionado con corticosteroides, con fórmula C25H33BrO6 y peso molecular de 509,43 g/mol. Desde el punto de vista estructural, corresponde a una modificación del esqueleto de budesonida en un centro carbonado halogenado, compatible con subproductos originados por bromación electrofílica o por la transformación de intermedios esteroideos protegidos. Su identidad se resuelve habitualmente por LC-MS/MS, con MS de alta resolución y confirmación ortogonal por LC-UV o RMN, ya que regioisómeros estrechamente relacionados pueden coeluir. En el contexto regulatorio, estas especies bromadas requieren vigilancia analítica estricta.
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