Bupropion 2-Cloro Analog (CAS 1049718-57-1) es una impureza estructural del perfil del bupropión caracterizada por la sustitución de un átomo de cloro en el anillo fenilo. Se genera como subproducto por cloración lateral o incorporación de impurezas en materia prima y puede complicar la purificación al presentar propiedades fisicoquímicas y de solubilidad similares al principio activo. Su detección y cuantificación requiere técnicas analíticas robustas como HPLC/UPLC con detección UV | LC-MS y RMN para confirmación estructural. El control se gestiona mediante optimización de la ruta sintética | etapas de purificación específicas y establecimiento de límites conforme a directrices regulatorias de perfil de impurezas.
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