Bupropion Related Compound C, CAS 152943-33-4, es una impureza cetónica aromática clorada vinculada a la ruta sintética de bupropión y puede originarse por sobre-reacción de un intermedio o por una elongación incompleta de la cadena lateral. Con fórmula molecular C9H9ClO2 y peso molecular de 184.62 g/mol, constituye una impureza de proceso estructuralmente definida más que un producto de degradación. Su motivo de clorocetona aromática exige alta selectividad analítica, por lo general mediante LC-MS/MS para cuantificación y confirmación a nivel traza, complementada con HPLC con detección por arreglo de diodos y, cuando la volatilidad lo permite, GC-MS. La evaluación regulatoria se centra en la especificación, el control de origen y la consistencia del perfil de impurezas.
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