Bupropion Related Compound E, también denominado Bupropion Dione Derivative, CAS 10557-17-2, es una impureza carbonílica clorada de bajo peso molecular con fórmula C9H7ClO2 y masa molecular de 182,6 g/mol. Estructuralmente corresponde a un motivo de aril cetona oxidada, coherente con un intermedio de síntesis o un producto de sobreoxidación generado durante la preparación de esqueletos relacionados con bupropión. Su función carbonilo electrofílica y la sustitución por cloro aromático exigen caracterización mediante LC-MS/MS y, cuando la volatilidad o la derivatización lo permitan, GC-MS, con confirmación por RMN para la asignación estructural. En el perfil de impurezas se considera su origen de proceso y su posible pertinencia en estrategias de control bajo ICH M7.
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