(αR)-3-Chloro-α-[(1R)-1-[(1, 1-dimethylethyl)amino]ethyl]-benzenemethanol and enantiomer
Sinónimos
rac Threo-Dihydro Bupropion
Descripción
Bupropion Dihidro isómero (R | R) y enantiómero (CAS 92264-82-9) es una impureza quiral relevante en procesos de síntesis de bupropion que exige control riguroso. Este contaminante presenta configuración (R | R) y enantiómeros asociados que pueden alterar el perfil de impurezas y la actividad farmacológica relativa | por lo que su identificación y cuantificación mediante HPLC quiral | LC-MS y RMN es esencial. Su presencia suele originarse por rutas de reducción incompleta o epimerización durante etapas de hidrogenación y purificación. Las estrategias de mitigación incluyen optimización de condiciones de reacción | cristalinidad y etapas de separación | validación analítica y límites de especificación conforme a guías regulatorias.
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