Impureza Bupropion (S)-Hydroxy Propanone Impurity (CAS 287477-53-6) es un subproducto estereoquímico relevante en la síntesis del bupropión que puede formarse por oxidación del intermedio propanona y por epimerización en condiciones acuosas ácidas o básicas. Su presencia afecta el perfil de impurezas del API y requiere monitoreo riguroso mediante HPLC con detección UV | espectrometría de masas y confirmación por RMN para determinar identidad y pureza. El control incluye optimización de condiciones de reacción | purificación por cristalización y límites de aceptación en especificaciones analíticas. Evaluaciones de estabilidad y estudios de degradación forense son esenciales para mitigarlo en el proceso de fabricación.
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