La impureza EP C de buspirona, también denominada impureza de buspirona bispirimidinilpiperazinil butano, es una impureza de proceso estructuralmente relacionada con el derivado piperazínico ansiolítico buspirona. El CAS 257877-45-5 corresponde a la entidad molecular C20H30N8 con un peso molecular de 382,51 g/mol. La sustancia representa un producto de sobrealquilación o de homología de cadena, coherente con rutas de síntesis, acoplamiento o alquilación, más que con una degradación oxidativa primaria. Su esqueleto heteroaromático, polibásico y muy polar exige caracterización ortogonal mediante LC-MS/MS, LC-MS de alta resolución y, cuando procede, confirmación por RMN. En el marco regulatorio se considera una impureza orgánica especificada.
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