Deoxy Epinephrine (CAS 501-15-5) es una impureza crítica encontrada en procesos de síntesis de adrenalina. Su presencia puede afectar la pureza farmacéutica y la estabilidad del producto final | por lo que el control de calidad exige identificación y cuantificación precisas. Se detecta mediante HPLC con detección UV y confirmación por espectrometría de masas | con límites de aceptación definidos por especificaciones regulatorias. El desarrollo de métodos validados de extracción y limpieza | así como la evaluación de riesgos de degradación e interacciones | es esencial para mitigar su impacto. El monitoreo rutinario y la documentación completa garantizan cumplimiento y seguridad en lotes comerciales.
Referencias
He, Huaibing, et al. “Determination of Catecholamines in Sheep Plasma by High-Performance Liquid Chromatography with Electrochemical Detection: Comparison of Deoxyepinephrine and 3, 4-Dihydroxybenzylamine as Internal Standard.â€Â Journal of Chromatography B: Biomedical Sciences and Applications, vol. 701, no. 1, Nov. 1997, pp. 115–19,  https://doi.org/10.1016/s0378-4347(97)00343-5.
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