Deoxy epinefrina (CAS 501-15-5) é uma impureza relacionada frequentemente observada em lotes de epinefrina | caracterizada por massa molecular e espectro UV distintos que permitem sua identificação por HPLC-UV e LC-MS/MS em perfil analítico de impurezas; seu aparecimento geralmente indica degradação oxidativa ou reações de desoxidação durante síntese ou armazenamento e pode afetar perfil de pureza | estabilidade e testes de identidade. Métodos validados de ensaio estabelecem limites de detecção e quantificação e fornecem suporte para investigação de causa raiz | classificação como impureza relacionada e avaliação do impacto em conformidade regulatória e controle de qualidade.
Referências
He, Huaibing, et al. “Determination of Catecholamines in Sheep Plasma by High-Performance Liquid Chromatography with Electrochemical Detection: Comparison of Deoxyepinephrine and 3, 4-Dihydroxybenzylamine as Internal Standard.â€Â Journal of Chromatography B: Biomedical Sciences and Applications, vol. 701, no. 1, Nov. 1997, pp. 115–19,  https://doi.org/10.1016/s0378-4347(97)00343-5.
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