DL-2-4-Carboxyphenyl propionic Acid (CAS 67381-50-4) es una impureza relevante en procesos sintéticos que involucran derivados arilpropiónicos. Se caracteriza por su estructura bicarbóxlica | solubilidad y perfil cromatográfico que pueden interferir en la cuantificación del producto principal. Su formación suele deberse a reacciones laterales como oxidación parcial o acoplamiento competitivo durante la esterificación y condiciones ácidas o básicas intensas. La detección y cuantificación se realiza por HPLC con detección UV y confirmación por LC-MS y RMN; controles cinéticos | optimización del pH y purificación por cristalización son estrategias eficaces para limitar su presencia en especificaciones y lotes.
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