La impureza de epinefrina 33 (isómero S) es un isómero quiral que puede formarse durante la síntesis o el almacenamiento de epinefrina y tiene impacto sobre la potencia | actividad y estabilidad del principio activo; su presencia requiere identificación y cuantificación precisas. El perfilado mediante HPLC quiral | LC-MS | GC-MS y RMN | junto con estudios de estrés y de epimerización | permite rastrear rutas de formación y degradación. Las estrategias de control incluyen síntesis enantioselectiva | resolución quiral y límites de especificación validados según normas de control de calidad para minimizar riesgos y asegurar consistencia del producto.
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