Epinephrine Impurity E (CAS 36467-25-1) | también conocida como Epinephrine BP Impurity E o N Benzyl Adrenalone | es una impureza relacionada que puede originarse durante la síntesis o la degradación de la epinefrina; presenta modificaciones estructurales detectables por espectrometría de masas y resonancia magnética nuclear. Su control analítico se realiza mediante métodos validados HPLC/UPLC y LC-MS para cuantificación y cumplimiento de especificaciones. La caracterización incluye perfil de impurezas | tiempos de retención | espectros UV y datos de masa. El monitoreo sistemático es esencial en control de calidad de materia prima y productos farmacéuticos para asegurar la pureza y homogeneidad del lote.
Referencias
Simons, F. Estelle. R., et al. “Epinephrine Absorption in Adults: Intramuscular versus Subcutaneous Injection.†Journal of Allergy and Clinical Immunology, vol. 108, no. 5, Nov. 2001, pp. 871–73, https://doi.org/10.1067/mai.2001.119409. ?
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