La impureza Hexanedioic Acid Mono-(2-carboxyphenyl) Ester (CAS 863985-44-8) es un éster monoaromático derivado del ácido hexanodioico que aparece por esterificación parcial o reacciones secundarias durante la síntesis. Presenta afinidad moderada por fases orgánicas | absorbancia UV detectable y susceptibilidad a hidrólisis y transesterificación bajo condiciones ácidas o básicas | lo que afecta perfiles de degradación y estabilidad. Su monitorización se realiza eficazmente por cromatografía líquida reversa con detección UV y confirmación por LC-MS; para análisis cualitativo pueden emplearse GC-MS tras derivatización. Se recomienda control de proceso | especificaciones de lote y estudios de estrés según ICH para limitar su impacto en pureza y seguridad del producto.
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