El aducto ribosa de pramipexol | presentado como mezcla de diastereómeros | constituye una impureza relevante en el perfil químico durante la síntesis y almacenamiento del principio activo. Su formación por glicación reductiva o reacción con azúcares residuales puede afectar pureza | actividad óptica y propiedades fisicoquímicas. Se recomienda su identificación y cuantificación por cromatografía líquida de alta resolución (HPLC) acoplada a espectrometría de masas (MS) y confirmación estructural mediante RMN 1H/13C y experimentos de correlación. El control analítico incluye límites especificados | estudios de degradación forzada para evaluar su aparición bajo estrés | y estrategias de purificación y prevención en procesos sintéticos para minimizar su presencia.
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