Rivaroxaban Impurity 126, CAS 148857-42-5, es un intermedio heteroaromático clorado asociado al perfil de impurezas sintéticas de rivaroxabán. Con fórmula molecular C11H10ClNO3 y peso molecular de 239,65 g/mol, su estructura es compatible con un subproducto de proceso originado por ciclación incompleta o arrastre de cadenas laterales durante la fabricación del núcleo aril oxazolidinona. El carácter aromático halogenado y la funcionalidad carbonilo polar favorecen una separación basada en cromatografía líquida en fase reversa, con detección por UV y LC-MS/MS, जबकि la confirmación elemental se apoya en HRMS. En evaluación regulatoria, estas impurezas relacionadas con la ruta se examinan bajo criterios de especificación y posible relevancia toxicológica conforme a los principios ICH.
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