La impureza 70 de rivaroxabán, CAS 89166-94-9, corresponde a C5H2Cl2O2S con un peso molecular de 197,03 g/mol. La estructura es coherente con un fragmento aromático clorado que contiene azufre, relacionado con intermedios derivados de tiofeno o cloruro de acilo, y puede originarse por acoplamiento incompleto, truncamiento de cadena lateral o fragmentación oxidativa durante la síntesis del proceso. Debido a su baja masa molecular y a la presencia de halógenos, su caracterización suele requerir LC-MS/MS y GC-MS ortogonales, complementadas por espectrometría de masas de alta resolución para definir la fórmula elemental. En el marco regulatorio, se evalúa como impureza relacionada con el proceso y, según la evidencia estructural, como posible preocupación genotóxica.
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