62572-94-5Betaxolol EP Impurity B (Free Base)

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Catalogue No.:	VL103014
CAS No.:	62572-94-5
Mol. Formula:	C14H23NO3
Mol. Weight:	253.34 g/mol

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Additional information on CAS 62572-94-5

Parent drug

Betaxolol/ Metoprolol

IUPAC Name

(2RS)-1-[4-(2-Hydroxyethyl)phenoxy]-3-[(1-methylethyl)amino]propan-2-ol

Pharmacopeial Synonyms

Metoprolol EP Impurity H; O-Desmethyl Metoprolol; Betaxolol Hydroxyethyl Analog

Synonyms

1-[4-(2-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-benzeneethanol

Smiles

CC(C)NCC(COC1=CC=C(C=C1)CCO)O

InChI

InChI=1S/C14H23NO3/c1-11(2)15-9-13(17)10-18-14-5-3-12(4-6-14)7-8-16/h3-6,11,13,15-17H,7-10H2,1-2H3

Shipping Condition

Ambient Temperature

Description

Metoprolol EP Impurity H (O-Desmethyl Metoprolol, Betaxolol Hydroxyethyl Analog), CAS 62572-94-5, is a structurally defined related impurity characterized by a 2-hydroxyethyl substitution on the phenoxy ring that increases polarity and modifies chromatographic properties compared with the parent substance. The free base 1-[4-(2-hydroxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol is readily identified and quantified using reversed-phase HPLC, LC-MS and proton NMR, exhibiting a distinct retention profile and diagnostic fragment ions. Monitoring this impurity supports impurity profiling, synthetic route assessment and stability evaluation where precise analytical standards and robust methods are required for regulatory control.