Enalapril EP Impurity E or Enalapril Phenylethyl Ester Analog or ((S)-1-oxo-1-phenethoxy-4-phenylbutan-2-yl)-L-alanyl-L-proline. Enalapril is a prodrug that is hydrolyzed after absorption to form the active angiotensin-converting enzyme Enalaprilat. It is administered orally. It decreases blood pressure by lowering peripheral resistance without increasing heart rate. It is well tolerated and safe.
References
Davies, Richard O., et al. “Enalapril Worldwide Experience.†The American Journal of Medicine, vol. 77, no. 2, Aug. 1984, pp. 23–35, https://doi.org/10.1016/s0002-9343(84)80055-8. ?Todd, Peter A., and Karen L. Goa. “Enalapril.†Drugs, vol. 43, no. 3, Mar. 1992, pp. 346–81, https://doi.org/10.2165/00003495-199243030-00005.
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