937-40-6N-Nitroso-N-methylbenzylamine (NBMA)(NMBzA)

● In Stock

Catalogue No.:	VE006112
CAS No.:	937-40-6
Mol. Formula:	C8H10N2O
Mol. Weight:	150.18 g/mol

Request a quote

Add to RFQ list

Additional information on CAS 937-40-6

Parent drug

Rivaroxaban/ N-Nitroso

IUPAC Name

N-Methyl-N-nitrosobenzenemethanamine

Pharmacopoeial Synonyms

N/A

Other Synonyms

Methylbenzylnitrosamine; N-benzyl-N-methylnitrous amide; Methyl-benzyl-nitrosoamin; Benzylamine, N-methyl-N-nitroso-; 1-Benzyl-1-methyl-2-oxohydrazine

Smiles

CN(CC1=CC=CC=C1)N=O

InChI

InChI=1S/C8H10N2O/c1-10(9-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

Shipping Condition

Ambient Temperature

Characterization Data (Included)

HPLC, MASS/LC-MS, 1H NMR, FT-IR, Potency, and Structure Elucidation Report (SER).

Additional Characterization Data

QNMR, D2O Exchange, 13C NMR, 13C APT, COSY NMR, NOESY NMR, 15N NMR, HSQC NMR, HMQC NMR, and HMBC NMR. These are available upon request and may be free or subject to additional charges.

Description

N-Nitroso-N-methylbenzylamine (NBMA), CAS 937-40-6, is a structurally defined nitrosamine impurity with molecular formula C8H10N2O and molecular weight 150.18 g/mol. As an N-nitrosated secondary amine derivative, it is of regulatory concern because nitrosamines are commonly treated as potential mutagenic impurities under ICH M7 frameworks. Formation may arise from nitrosating conditions affecting N-methylbenzylamine precursors or related synthetic intermediates. Due to low-level occurrence and matrix complexity, characterization typically relies on LC-MS/MS and GC-MS, often with selective ion monitoring and confirmatory fragmentation to distinguish it from structurally related nitroso species.

References

Hsia, C. -C ., et al. ?Enhancement of Formation of the Esophageal Carcinogen Benzylmethylnitrosamine from Its Precursors by Candida Albicans.? Proceedings of the National Academy of Sciences, vol. 78, no. 3, Mar. 1981, pp. 1878?81, https://doi.org/10.1073/pnas.78.3.1878.?