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624742-53-6Pantoprazole EP Impurity D
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| Catalogue No.: | VE009260 |
|---|---|
| CAS No.: | 624742-53-6 |
| Mol. Formula: | C17H17F2N3O4S |
| Mol. Weight: | 397.40 g/mol |
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Additional information on CAS 624742-53-6
Parent drug
PantoprazoleIUPAC Name
(R)-5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1-methyl-1H-benzo[d]imidazoleSmiles
CN1C([S@@](CC2=NC=CC(OC)=C2OC)=O)=NC3=CC(OC(F)F)=CC=C13Pharmacopeial Synonyms
Pantoprazole BP Impurity D; Pantoprazole Related Compopund DSynonyms
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1-methyl; N1-Methyl pantoprazoleInChI
InChI=1S/C17H17F2N3O4S/c1-22-13-5-4-10(26-16(18)19)8-11(13)21-17(22)27(23)9-12-15(25-3)14(24-2)6-7-20-12/h4-8,16H,9H2,1-3H3/t27-/m1/s1Pharmacopoeial Synonyms
Pantoprazole BP Impurity D; Pantoprazole Related Compopund DOther Synonyms
1H-Benzimidazole, 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1-methyl; N1-Methyl pantoprazoleInChl
InChI=1S/C17H17F2N3O4S/c1-22-13-5-4-10(26-16(18)19)8-11(13)21-17(22)27(23)9-12-15(25-3)14(24-2)6-7-20-12/h4-8,16H,9H2,1-3H3Description
Pantoprazole EP Impurity D, also listed as Pantoprazole BP Impurity D and Pantoprazole Related Compound D, CAS 624742-53-6, is the N1-methyl analog of pantoprazole and an oxidized benzimidazole sulfoxide impurity with molecular formula C17H17F2N3O4S and molecular weight 397.40 g/mol. Its presence is typically associated with methylation-related process impurities or incomplete control of sulfoxide chemistry during synthesis of the proton pump inhibitor. Because structurally related heteroaromatic impurities can influence impurity profiles at low levels, characterization generally requires LC-MS/MS, LC-HRMS, and orthogonal HPLC methods, with MS fragmentation used to confirm substitution on the benzimidazole and pyridine moieties.References
Bernshteyn, Michelle A., and Umair Masood. “Pantoprazole.†Nih.gov, StatPearls Publishing, 15 Jan. 2022, www.ncbi.nlm.nih.gov/books/NBK499945/. ‌Request a Quote
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