Telmisartan Chloro Impurity, also designated Telmisartan Impurity J, is a chlorinated process-related impurity associated with the biphenyl benzimidazole scaffold of telmisartan. CAS 885045-90-9 corresponds to C33H29ClN4O2, molecular weight 549.06 g/mol. Its structure is consistent with a halogenated synthetic byproduct arising from chlorination or incomplete substitution control during assembly of the aryl chloride intermediate. Because such analogues may persist at trace levels, characterization commonly requires LC-MS/MS for mass confirmation, LC-UV for profile separation, and orthogonal LC-HRMS or NMR for structural assignment. In regulatory assessment, this impurity is evaluated as a process impurity rather than a classic genotoxic species.
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