144702-27-2Telmisartan EP Impurity G

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Catalogue No.:	VL142016
CAS No.:	144702-27-2
Mol. Formula:	C33H29N5
Mol. Weight:	495.62 g/mol

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Additional information on CAS 144702-27-2

Parent drug

Telmisartan

IUPAC Name

4′-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl][1,1′-biphenyl]-2-carbonitrile

Pharmacopoeial Synonyms

N/A

Other Synonyms

Telmisartan Cyano Analog; 2-Descarboxy-2-Cyano Telmisartan; (1,1′-Biphenyl)-2-carbonitrile, 4′-((1,4′-dimethyl-2′-propyl(2,6′-bi-1H-benzimidazol)-1′-yl)methyl)-; 4′-[(1,4′-dimethyl-2′-propyl [2,6′-bi-1H-benzimidazol]-1′-yl)methyl]-[1,1′-biphenyl]-2-carbonitrile

Smiles

CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C=C(C=C2C)C5=NC6=CC=CC=C6N5C

InChI

InChI=1S/C33H29N5/c1-4-9-31-36-32-22(2)18-26(33-35-28-12-7-8-13-29(28)37(33)3)19-30(32)38(31)21-23-14-16-24(17-15-23)27-11-6-5-10-25(27)20-34/h5-8,10-19H,4,9,21H2,1-3H3

Description

Telmisartan EP Impurity G, also described as the cyano analog or 2-descarboxy-2-cyano telmisartan free base, is a structurally related process and degradation impurity associated with the benzimidazole biphenyl tetrazole architecture of telmisartan. Its molecular formula is C33H29N5, molecular weight 495.62 g/mol, CAS 144702-27-2. The cyano substituent and absence of the carboxylate functionality indicate a decarboxylative transformation, consistent with synthetic byproduct formation or stress-mediated degradation during thermal or acidic exposure. Characterization commonly requires LC-MS/MS, high-resolution MS, and orthogonal HPLC or NMR confirmation, with regulatory evaluation under impurity profiling and ICH Q3A/Q3B principles.